Biochemical and Biophysical Research Communications
Volume 388, Issue 2, 16 October 2009, Pages 252-255
Non-enzymatic cyclization of creatine ethyl ester to creatinine
Matthew W. Giese, a, and Carl S. Lechera
aDepartment of Chemistry, Marian University, 3200 Cold Spring Rd., Indianapolis, IN 46222, USA
Received 28 July 2009. Available online 4 August 2009.
Abstract
Creatine ethyl ester was incubated at 37 ?C in both water and phosphate-buffered saline and the diagnostic methylene resonances in the 1H NMR spectrum were used to identify the resultant products. It was found that mild aqueous conditions result in the cyclization of creatine ethyl ester to provide inactive creatinine as the exclusive product, and this transformation becomes nearly instantaneous as the pH approaches 7.4. This study demonstrates that mild non-enzymatic conditions are sufficient for the cyclization of creatine ethyl ester into creatinine, and together with previous results obtained under enzymatic conditions suggests that there are no physiological conditions that would result in the production of creatine. It is concluded that creatine ethyl ester is a pronutrient for creatinine rather than creatine under all physiological conditions encountered during transit through the various tissues, thus no ergogenic effect is to be expected from supplementation.
Told ya
Εμφάνιση αποτελεσμάτων : 1 έως 13 από 13
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16-10-09 19:53 #1H CEE μαλλον ειναι αχρηστηVictory is reserved for those who are willing to pay its price. - Sun Tzu
It does not matter how slowly you go so long as you do not stop. - Confucius
scientia potentia est/Η Γνώση είναι Δύναμη - Francis Bacon
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19-10-09 18:27 #2
μια επεξηγηση??αυτο πρωτη φορα το ακουω
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19-10-09 19:20 #4
Tα ελεγε αυτα ο Layne..εδω και χρονια!προσφατα ειδα και ενα πινακακι με την "κατακρατηση" υγρων ενδομυικα λογω των διαφορων τυπων κρεατινης..η CEE τα ριχνει πιο κατω και απο τα φυσιολογικα αν θυμαμαι καλα... μαπα το καρπουζι
Carbs "Burn Them Or Wear Them"
DoggCrapp follower
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20-10-09 17:43 #5
και η KRE-ALKALYN τετοια ειναι???
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20-10-09 20:23 #6Victory is reserved for those who are willing to pay its price. - Sun Tzu
It does not matter how slowly you go so long as you do not stop. - Confucius
scientia potentia est/Η Γνώση είναι Δύναμη - Francis Bacon
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20-10-09 21:32 #7
Δείτε και αυτό
The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels.
Spillane M, Schoch R, Cooke M, Harvey T, Greenwood M, Kreider R, Willoughby DS
Department of Health, Human Performance and Recreation, Baylor University, Box 97313, Waco, TX 76798, USA. darryn_willoughby@baylor.edu.
ABSTRACT: Numerous creatine formulations have been developed primarily to maximize creatine absorption. Creatine ethyl ester is alleged to increase creatine bio-availability. This study examined how a seven-week supplementation regimen combined with resistance training affected body composition, muscle mass, muscle strength and power, serum and muscle creatine levels, and serum creatinine levels in 30 non-resistance-trained males. In a double-blind manner, participants were randomly assigned to a maltodextrose placebo (PLA), creatine monohydrate (CRT), or creatine ethyl ester (CEE) group. The supplements were orally ingested at a dose of 0.30 g/kg fat-free body mass (approximately 20 g/day) for five days followed by ingestion at 0.075 g/kg fat free mass (approximately 5 g/day) for 42 days. Results showed significantly higher serum creatine concentrations in PLA (p = 0.007) and CRT (p = 0.005) compared to CEE. Serum creatinine was greater in CEE compared to the PLA (p = 0.001) and CRT (p = 0.001) and increased at days 6, 27, and 48. Total muscle creatine content was significantly higher in CRT (p = 0.026) and CEE (p = 0.041) compared to PLA, with no differences between CRT and CEE. Significant changes over time were observed for body composition, body water, muscle strength and power variables, but no significant differences were observed between groups. In conclusion, when compared to creatine monohydrate, creatine ethyl ester was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power. Therefore, the improvements in these variables can most likely be attributed to the training protocol itself, rather than the supplementation regimen.
Αυτή είναι η έρευνα αν δεν κάνω λάθος ...The last three or four reps is what makes the muscle grow. This area of pain divides the champion from someone else who is not a champion. That's what most people lack, having the guts to go on and just say they'll go through the pain no matter what happens.
Arnold Schwarzenegger
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21-10-09 00:56 #8
- Εγγραφή
- 17-09-2009
- Μηνύματα
- 199
Η κρεατινη ειναι πια πολυ φτηνη και ψαχνουν πως θα σε κανουν να παρεις κατι αλλο μαζι της για να σου αδειασουν το πορτοφολι.Παιρνουν μιση ερευνα που εγινε σε δυόμιση ποντίκια στην Ζανζιβάρη και βαση αυτης τσουπ αμεσως το νεο σουπερ-ντουπερ προϊον που διαφοροποιειται αισθητα απο τον ανταγωνισμο
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21-10-09 01:47 #9
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21-10-09 12:02 #10Victory is reserved for those who are willing to pay its price. - Sun Tzu
It does not matter how slowly you go so long as you do not stop. - Confucius
scientia potentia est/Η Γνώση είναι Δύναμη - Francis Bacon
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03-11-09 21:07 #11
Λοιπόν, αυτή είναι η τελευταία εβδομάδα(6) χρήσης CCE. Είχα την CellMass (BSN), όπως είχα πει την πήρα τσάμπα γι' αυτό και τη δοκίμασα.
Ακόμη και τώρα δεν έχω δει τρομερά πρηξίματα, ούτε μεγάλη κατακράτηση νερού. Ούτε ανέβηκα πολύ σε δύναμη, άντε να πήρα 5-10 κιλά στις βασικες, αλλα ίσως ανέβαινα ούτως η άλλως γιατί μαζί με τη κρεατίνη ξεκίνησα και σωστή διατροφή. Μετά τη δοκιμή πάνω μου μπορώ να πω πως όντως δεν κάνει δουλειά.ὓβρις→ἂτη→νέμεσις→τίσις
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18-04-10 22:01 #12
Τελευταία επεξεργασία από το χρήστη Svein : 19-04-10 στις 15:01
www.bodybuilding.gr The Name You Trust !!!!
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19-04-10 03:24 #13
- Εγγραφή
- 07-11-2007
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- Natural World
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- 776
συμφωνω πως ειναι αχρηστη..τελειως ομως!μονουδρωτικη...και παλι monohydrate